Pathogenesis of cervical cancer

Spread to adjacent pelvic organs Spread to distant organs Adapted from FIGO staging for carcinoma of the vulva, cervix, and corpus uteri. Int J Gynaecol Obstet ; 2:

Pathogenesis of cervical cancer

Both of these lesions require follow-up as described below in the Follow-up of Abnormal Pap Test Results section. HPV infection the primary cause of cervical cell abnormalities: Cervical Pathogenesis of cervical cancer intraepithelial lesions CSIL arise at the junction of cervical squamous and columnar epithelium around the cervical os.

Glandular carcinoma makes up the remaining type of cervical cancer [International Collaboration of Epidemiological Studies of Cervical Cancer ].

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The primary cause of cervical cell abnormalities is HPV infection. HPV can be categorized as high risk cancer causing or low risk benign warts on the basis of oncogenic potential.

High-risk types that are related to anogenital cancers include types 16, 18, 26, 31, 33, 35, 39, 45, 51, 52, 56, 58, 59, 68, 69, 70, 73, and 82 [Guan et al. Among females with HIV, high-risk types 51, 52, 53, 56, 58, and 59 are more common than types 16 and 18 [Hariri et al.

Of the low-risk types 6, 11, 13, 40, 42, 43, 44, 53, 54, 61, 62, 72, 73, 74, and 816 and 11 are most commonly associated with benign disease genital warts.

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Identifying the presence of high-risk HPV types can assist in the management of abnormal Pap test results in females with and without HIV [Hariri et al.

Immunocytochemistry staining of cervical cells on cytology for p16 seen in dysplastic cervical cells but not normal cells and Ki which can be seen in HPV-positive and HPV-negative cells has been studied in patients without HIV [Dona et al. The utility of this adjunctive testing on cytology is not clear.

Immunocytochemistry staining has not been studied in females with HIV.

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Abnormal cervical cytology requires close follow-up and referral for colposcopy: HSIL Pap test results suggest that a lesion is more likely to be precancerous. Colposcopy is not considered cost-effective as a primary screening test for females with or without HIV.

Glandular carcinoma of the cervix may be preceded by a negative Pap test or a test indicating the presence of atypical glandular cells AGC [Moukarzel et al. AGC on a Pap test may indicate a precursor lesion for a glandular cell cervical cancer, which is rare, and also may be related to HPV infection.

AGC also may be a contaminant from endometrial or fallopian tube cancer.

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Abnormal cervical cytology should be followed up with colposcopy, which facilitates location of a specific lesion for biopsy and histologic diagnosis. An AGC Pap result requires immediate follow-up with colposcopy and further evaluation.

Treatment decisions are based on the resulting tissue diagnosis. Squamous intraepithelial lesions on the vaginal cuff can be seen as recurrent disease after hysterectomy in females with a history of CSIL and as primary disease in females post-hysterectomy, not related to cervical disease [Saslow et al.

The presence of high-risk HPV and an abnormal Pap test indicates greater risk of precancerous disease and requires more intensive follow-up to ensure that precancerous lesions are not missed.

HPV co-testing is not indicated for individuals younger than 30 years because spontaneous clearance of HPV infection and cervical neoplasia often occur in younger females regardless of HIV status [Plummer et al. Aggressive treatment of dysplasia from transient HPV infection may damage the cervix and could be more harmful than beneficial in this age group [Bruinsma and Quinn ; Conner et al.

Females with HIV, a normal Pap test, and a positive high-risk HPV test result have four times the risk of having an abnormal finding on colposcopy [Musa et al.

Pathogenesis of cervical cancer

Data to support the safety of using HPV co-testing to extend intervals of cervical screening to every 5 years are limited to studies of females without HIV [Moyer ]. HPV co-testing, in lieu of cervical cytology alone performed every 3 years, has been used to extend cervical cytologic screening to 5 years in females without HIV [Committee on Practice Bulletics—Gynecology ].

When both HPV and Pap test results are negative, extension of cervical screening to every 5 years may be appropriate in individuals with HIV who have stable viral suppression and immune competence.

Conversely, individuals who present with intractable or recurrent CSIL after treatment may be demonstrating HIV progression and immune suppression.

HIV viral load and CD4 cell count testing for these individuals may identify individuals who may benefit from a re-evaluation of their HIV disease treatment [Paramsothy et al.Role of NYS Primary Care Providers.

For patients with HIV infection, primary care clinicians, including mid-level care providers, have a major role in the screening, diagnosis, and treatment of gynecologic comorbidities and especially cervical dysplasia and cervical cancer.

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Cancer Biomarkers. A cancer biomarker refers to a substance or process that is indicative of the presence of cancer in the body. A biomarker may be a molecule secreted by a tumor or a specific response of the body to the presence of cancer. Genetic, epigenetic, proteomic, glycomic, and imaging biomarkers can be used for cancer diagnosis, prognosis, and epidemiology.

The Cancer Genome Atlas (TCGA) is a comprehensive and coordinated effort to accelerate our understanding of the molecular basis of cancer through the application of genome analysis technologies, including large-scale genome sequencing.

11 Signs It's More Serious Than the Common Cold 2 11 Signs It's More Serious Than the Common Cold Doctors explain how to tell if you have the common cold or something more. Pathogenesis of cervical cancer CIN and squamous cell cervical carcinoma It is widely accepted that invasive squamous cell carcinoma of the cervix, which is the commonest histological type, is preceded by a pre-invasive stage of the disease, where the abnormal cells are confined to the epithelium.

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